This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (14)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Clinicopathological Correlative Study in Adults With Lupus Glomerulonephritis and Various Renal Diseases

Robert E. Bond, MD; James V. Donadio, Jr., MD; Keith E. Holley, MD; E. J. Walter Bowie, BM, BCh

Arch Intern Med. 1973;132(2):182-187.

Abstract
Fibrinolytic split product (FSP) levels were correlated with renal biopsy results in 25 adults with lupus glomerulonephritis and 23 adults with other renal diseases. The FSP levels were elevated in 42 of the 48 patients. Other coagulation studies showed increased plasma fibrinogen levels in 29 of 33 patients, positive ethanol gelation reactions, and prolonged prothrombin, thrombin, or plasma clot times. All platelet counts were normal or slightly elevated. In glomerular capillaries of lupus nephritis patients, elevated FSP levels correlated best with fibrinoid presence, and, to a lesser degree, with fibrin. There were no relationships between FSP levels and glomerular lesions in patients with other renal diseases. Although there was reliable clinical and pathologic evidence for intravascular coagulation in these renal disease patients, the pathogenetic role of intravascular coagulation in destructive and progressive renal lesions in man remains unknown.

Author Affiliations
Rochester, Minn

From the Mayo Clinic and the Mayo Foundation, Rochester, Minn.

Footnotes
Received for publication March 13, 1972; accepted July 7.

Reprint requests to Section of Publications, Mayo Clinic, Rochester, Minn 55901.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Thrombophlebitis in Systemic Lupus Erythematosus
Peck et al.
JAMA 1978;240:1728-1730.
ABSTRACT  

The Spectrum of Vitamin K Deficiency
Ansell et al.
JAMA 1977;238:40-42.
ABSTRACT  

Renal Vein Thrombosis, Nephrotic Syndrome, and Systemic Lupus Erythematosus: An Association in Four Cases
APPEL et al.
ANN INTERN MED 1976;85:310-317.
ABSTRACT  

Systemic Lupus Erythematosus: Contrasts and Comparisons
DECKER et al.
ANN INTERN MED 1975;82:391-404.
ABSTRACT