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Effect of Intravenously Given Parathyroid Extract on Urinary Excretion of Connective Tissue Components

John H. Bland, MD; Barry Kirschbaum, MD; Gerald T. O'Connor; Elbert Whorton, PhD

Arch Intern Med. 1973;132(2):209-212.

Abstract
The effect of parathyroid extract infusion was studied in a 17-year-old boy with myositis ossificans progressiva to evaluate its effect on excretion of connective tissue components in extensive ectopic ossification and to explore its therapeutic potential. There was an increase in urinary excretion of hydroxyproline, hexosamine, glycosaminoglycans, and phosphorus, and a decrease in calcium excretion after each infusion. No apparent therapeutic effect was achieved. The hydroxyproline response suggested unusual sensitivity to parathyroid extract, either because of an increased relatively soluble collagen pool or an increased ability to produce hydrolases (collagenase, glycosaminoglycan depolymerases) in response to parathyroid extract stimulus.

Author Affiliations
Burlington, Vt

From the departments of medicine (Drs. Bland and Kirschbaum and Mr. O'Connor) and community medicine (Dr. Whorton), University of Vermont, College of Medicine, Burlington.

Footnotes
Received for publication Dec 2, 1971; accepted April 5, 1973.

Reprint requests to Department of Medicine, Rheumatology Unit, University of Vermont, College of Medicine, Burlington, VT 05401 (Dr. Bland).

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