This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (45)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Myelodysplastic Syndrome Often Terminating in Acute Leukemia

William B. Fisher, MD; Steven A. Armentrout, MD; Russell Weisman, Jr., MD; Richard C. Graham, Jr., MD

Arch Intern Med. 1973;132(2):226-232.

Abstract
"Preleukemia" is a hematologic disorder frequently terminating in acute nonlymphoblastic leukemia in adults. The salient features of this syndrome include the following: (1) a decrease in the number of at least one cell line in the peripheral blood; (2) a hypercellular bone marrow with distinct abnormalities in both the erythroid and granulocytic cell lines; (3) an insidious onset, usually beginning after the age of 50 years; and (4) a high probability of termination in acute leukemia. There is evidence that preleukemia represents a myeloproliferative disorder. Review of the literature indicates that this disorder is variable in duration (2 to 108 months) and occurs frequently.

Author Affiliations
Cleveland

From the Department of Medicine, University Hospitals of Cleveland, Case Western Reserve University, Cleveland.

Footnotes
Received for publication Feb 21, 1972; accepted Sept 12.

Reprint requests to 101 Manchester Ave, Orange, CA 92668 (Dr. Armentrout).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Classification of Acute Leukemia
GRALNICK et al.
ANN INTERN MED 1977;87:740-753.
ABSTRACT