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Its Relationship to Coronary Heart Disease Risk Factors and Cardiovascular Disease, Evans County, Georgia

Ronald Klein, MD, MPH; Barbara E. Klein, MD, MPH; Joan C. Cornoni, MPH, PhD; Jo Maready; John C. Cassel, MD, MPH; Herman A. Tyroler, MD

Arch Intern Med. 1973;132(3):401-410.

Abstract
Analysis of serum uric acid (SUA) data obtained during the second examination of 2,530 persons in Evans County, Georgia, revealed a mean SUA level of 5.7 and 5.6 mg/100 ml for white and black males, respectively, and 4.8 and 4.9 mg/100 ml for white and black females, respectively. The SUA level and ponderal index were negatively correlated in all four race-sex groups. The prevalence of hypertension was greater in hyperuricemics as compared to normouricemics in all race-sex groups. Increased prevalence of coronary heart disease in hyperuricemics was secondary to increased body size. We review hypotheses concerning the relationships between SUA and coronary risk factors, hypertension, and coronary heart disease.

Author Affiliations
Research Triangle Park, NC; Chapel Hill, NC

From the pathologic physiology branch (Dr. R. Klein), National Institute of Environmental Health Sciences, Research Triangle Park, NC; and departments of epidemiology (Ms. Maready and Drs. Cornoni, Cassel, and Tyroler) and preventive medicine (Dr. B. Klein), University of North Carolina, Chapel Hill, NC. Dr. R. Klein is now at the Bascom Palmer Eye Institute, Miami, Fla.

Footnotes
Received for publication Dec 11,1972; accepted April 4, 1973.

Reprint requests to Bascom Palmer Eye Institute, 1638 NW Tenth Ave, Miami, FL 33136 (Dr. R. Klein).

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