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Effects on Mortality in Coronary Disease

Richard H. Reynertson, MD; Manuel Tzagournis, MD

Arch Intern Med. 1973;132(5):649-653.

Abstract
A prospective study of 137 patients aged 50 years or less with coronary heart disease was begun in 1965. Twenty-seven patients have died during the course of the study, all from cardiovascular causes. Clinical and metabolic characteristics on entry into the study have been related to subsequent mortality. The findings suggest that an elevated base line serum cholesterol level is associated with a significantly increased mortality. Myocardial infarction rather than angina pectoris at entry into the study, as well as duration of symptomatic coronary disease prior to entry, were characteristics adversely affecting survival. Serum triglyceride levels, glucose tolerance, immunoreactive insulin responses to orally ingested glucose, and body weight did not appear to affect survival in persons with established coronary heart disease.

Author Affiliations
Columbus, Ohio

From the Department of Medicine, Division of Endocrinology and Metabolism, Ohio State University Hospitals, Columbus. Dr. Reynertson is now at the Department of Medicine, University of Alabama, Birmingham.

Footnotes
Received for publication Sept 25, 1972; accepted Feb 9, 1973.

Reprint requests to 410 W 10th Ave, Columbus, OH 43210 (Dr. Tzagournis).

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