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Hypoinsulinemia of Hypothyroidism
Jayendra H. Shah, MB, BS, MCPS;
Gerard M. Cerchio, MD
Arch Intern Med. 1973;132(5):657-661.
Abstract
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To understand carbohydrate intolerance of hypothyroidism, glucose and insulin responsiveness was studied in eight patients before and after treatment. A striking early hypoinsulinemia in response to intravenously administered glucose has been observed. Fasting levels of plasma glucose and serum insulin were normal and remained unchanged after treatment, while glucose disappearance rates were significantly improved following therapy (P<05). During hypothyroidism, substantial insulin release was not detected until four minutes after onset of glucose infusion, and the mean maximal response was not achieved until six minutes. In contrast, despite identical glucose levels during the first seven minutes, the euthyroid state was associated with a prompt rise at three minutes, reaching maximal insulin response at four or five minutes. These results indicate that hypothyroidism is characterized by diminution of the acute insulin response, similar to that observed in some patients with maturity-onset diabetes, which may be responsible for the impaired glucose tolerance observed
Author Affiliations
Chicago
From the Abraham Lincoln School of Medicine, University of Illinois College of Medicine, Chicago.
Footnotes
Received for publication Nov 20, 1972; accepted Feb 6, 1973.
Read in part before the Fourth International Congress of Endocrinology, Washington, DC, June 22, 1972.
Reprint requests to Endocrine-Metabolic Research Laboratory, Rm A259, MP 172, Veterans Administration West Side Hospital, PO Box 8195, Chicago 60680 (Dr. Shah).
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