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Alterations During Stressful Underwater Demolition-Team Training

Leonard M. Zir, MD; LCDR William B. McHugh, MC, USN; CDR Richard H. Rahe, MC, USNR; CAPT Ransom J. Arthur, MC, USN; Robert T. Rubin, MD

Arch Intern Med. 1973;132(6):808-812.

Abstract
Sixteen, randomly-selected, physically fit, young men, undergoing a vigorous, four-month, underwater demolition-team training program, showed marked alterations in their serum uric acid concentrations that could not be accounted for by simultaneous alterations in their urinary indices of either uric acid production or excretion. Significant elevations in subjects' serum uric acid levels corresponded to periods of mental alertness and preparedness on their parts to meet with new challenges in training. The elevations seen in subjects' serum uric acid concentrations at these times may have been due to changes in their blood or plasma volume, secondary to a release of adrenal catecholamines.

Author Affiliations
San Diego, Calif; Torrance, Calif

From the Biochemical Correlates Division, Medical Neuropsychiatric Research Unit, San Diego, Calif (Drs. Zir, McHugh, Rahe, and Arthur) and the Department of Psychiatry, University of California at Los Angeles, Harbor General Hospital, Torrance (Dr. Rubin).

Footnotes
Received for publication, Oct 13, 1972; accepted Feb 5, 1973.

The opinions expressed herein are those of the authors and are not to be construed as necessarily reflecting the official view or endorsement of the Department of the Navy.

Reprint requests to Navy Medical Neuropsychiatric Research Unit, San Diego, Calif 92152 (Dr. Rahe).

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