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Prostaglandins, Inflammation, and Asthma
Robert B. Zurier, MD
Arch Intern Med. 1974;133(1):101-110.
Abstract
There is evidence to suggest that prostaglandins participate in the mediation of the inflammatory response. In several tissues, the production of inflammation has been associated with the release of prostaglandin. The inhibitory effect of some anti-inflammatory agents on prostaglandin synthesis further suggests a prostaglandin role in inflammation. Prostaglandins may also play a role in the pathogenesis and treatment of asthma. The E prostaglandins are potent bronchodilators, whereas the F compounds are bronchoconstrictors. In addition, PGE2 prevents bronchoconstriction induced by agents such as histamine, serotonin, bradykinin, and acetylcholine. There is evidence to suggest that in addition to their effects on bronchial smooth muscle, prostaglandins may also have an antiallergic activity that may prove useful in the treatment of asthma.
Author Affiliations
Farmington, Conn
From the Department of Medicine, New York University School of Medicine, New York, NY. Dr. Zurier is now with the University of Connecticut School of Medicine, Farmington.
Footnotes
Received for publication Aug 17, 1973; accepted Aug 20.
Reprint requests to the Department of Medicine, University of Connecticut School of Medicine, Farmington, CT
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