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Substances That Inhibit the Actions of Prostaglandins
John H. Sanner, PhD
Arch Intern Med. 1974;133(1):133-146.
Abstract
Several substances have been found to inhibit some actions of prostaglandins. Three principal types have shown characteristics of specific, competitive prostaglandin antagonism. These are dibenzoxazepine derivatives (especially SC-19220), 7-oxa-prostaglandin analogs (especially 7-oxa-13-prostynoic acid), and phosphorylated polymers of phloretin (especially polyphloretin phosphate).
As more is learned about prostaglandins, more evidence is accumulating that they may be involved in certain pathological conditions. This has led to suggestions that prostaglandin antagonists may be useful therapeutic agents for treating conditions such as habitual abortion, premature labor, diarrhea, cerebral vasospasm, fever, bone resorption, sickle cell anemia, obstructive lung diseases, inflammation, uveitis, and glaucoma. No proved therapeutic utility has been established for prostaglandin antagonists, but research in animals has indicated that some of the suggested uses may be practical.
Author Affiliations
Chicago
From the Department of Biological Research, Searle Laboratories Division, G. D. Searle and Company, Chicago.
Footnotes
Received for publication Aug 17, 1973; accepted Aug 20.
Reprint requests to Box 5110, Chicago 60680.
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