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Cardiovascular-Renal Effects of ProstaglandinsThe Antihypertensive, Natriuretic Renal "Endocrine" Function
James B. Lee, MD
Arch Intern Med. 1974;133(1):56-76.
Abstract
There is evidence to suggest that the regulation of systemic blood pressure by the kidney is, in part, an expression of a renal antihypertensive endocrine function, that sodium secretion by the kidney may be related to the presence of a natriuretic "hormone," and that intrarenal prostaglandins may be involved in the mechanisms of both of these renal functions. Prostaglandin (PGA and PGE) compounds, when administered to hypertensive man, decrease blood pressure, increase renal blood flow, and promote a water and sodium diuresis. Circulating plasma PGA concentrations have been found to be lower in hypertensive man than in the normotensive state. Mechanisms are proposed by which PGA or PGE may function as an intrarenal hormone and by which PGA may function as a circulating hormone to regulate blood pressure.
Author Affiliations
Buffalo
From the State University of New York at Buffalo School of Medicine and Buffalo General Hospital.
Footnotes
Accepted for publication Aug 17, 1973.
Reprint requests to Buffalo General Hospital, 100 High St, Buffalo 14203 (Dr. Lee).
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