 |
|
Hemolysis in Sickle Cell Disease
Thomas A. Bensinger, MD;
Peter N. Gillette, MD
Arch Intern Med. 1974;133(4):624-631.
Abstract
The existence of hemolysis in sickle cell disease has been documented by both indirect and direct methods. The existence of bone-marrow erythroid hyperplasia, reticulocytosis, indirect hyperbilirubinemia, and elevations of plasma hemoglobin and serum lactic acid dehydrogenase values show hemolytic disease. Direct studies of erythrocyte survival, including the Ashby differential agglutination technique as well as isotopic methods have all shown a markedly decreased red blood cell survival in the range of 10 to 30 days mean cell life-span. Data obtained by means of endogenous production of carbon monoxide have shown that the mean rate of heme catabolism is approximately six times normal but varies from 3 to 14 times normal in individual patients. These data document, by a relatively new technique, the consistent presence of a severe hemolytic process in sickle cell anemia.
Author Affiliations
Washington, DC; New York
From the Department of Hematology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, DC (Dr. Bensinger) and Rockefeller University, New York (Dr. Gillette). Dr. Bensinger is now at the City of Hope National Medical Center, Duarte, Calif.
Footnotes
Received for publication Sept 17, 1973; accepted Sept 17.
Reprint requests to 1500 E Duarte Rd, Duarte, CA 91010 (Dr. Bensinger).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease
Kato et al.
Blood 2006;107:2279-2285.
ABSTRACT
| FULL TEXT
Abnormal haemoglobins, Hb Takamatsu and Hb G-Szuhu, detected during the analysis of glycated haemoglobin (HbA1C) by high performance liquid chromatography
Moriwaki et al.
J. Clin. Pathol. 2000;53:854-857.
ABSTRACT
| FULL TEXT
|
