 |
|
The Treatment of Sickle Cell Anemia
Samuel Charache, MD
Arch Intern Med. 1974;133(4):698-705.
Abstract
"Sickle cell crisis" is a diagnosis made by exclusion, and infection must be ruled out as a cause of symptoms whenever a patient becomes acutely ill. Partial exchange transfusion is an important therapeutic tool, for it seems to interrupt "the vicious cycle of sickling" in some instances and forestall it in others. Child-bearing is an acceptable risk if the woman wants to raise a family, but oral contraceptives are probably safer than an undesired pregnancy. No drug is now recognized as an effective agent for prevention or termination of painful crises. Sodium cyanate and long-term transfusion need careful evaluation as means of treatment, but great care must be exercised to inform patients of both risks and benefits of any new regimen.
Author Affiliations
Baltimore
From the Department of Medicine, Johns Hopkins University School of Medicine and Johns Hopkins Hospital.
Footnotes
Received for publication June 12, 1973; accepted June 15.
Reprint requests to 601 N Broadway, Baltimore 21205 (Dr. Charache).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
A Case of Topical Benzocaine-Induced Methemoglobinemia
Granko
Journal of Pharmacy Practice 2002;15:75-78.
ABSTRACT
Risk of Alloimmunization and Delayed Hemolytic Transfusion Reactions in Patients With Sickle Cell Disease
Cox et al.
Arch Intern Med 1988;148:2485-2489.
ABSTRACT
Sickle Cell Anemia
Johnson
JAMA 1985;254:1958-1963.
ABSTRACT
Delayed Hemolytic Transfusion Reaction Presenting as Sickle-Cell Crisis
DIAMOND et al.
ANN INTERN MED 1980;93:231-234.
ABSTRACT
Hematology-Oncology: An Annotated Bibliography of Recent Literature: References to Journal Articles and Other Papers
HEMATOLOGY-ONCOLOGY COMMITTEE
ANN INTERN MED 1976;84:758-762.
ABSTRACT
|
