This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (83)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Harriet R. Dustan, MD; Robert C. Tarazi, MD; Emmanuel L. Bravo, MD

Arch Intern Med. 1974;133(6):1007-1013.

Abstract
Diuretic drugs and low-sodium diets are effective in control of hypertension. They seem to have a similar mechanism of action that is dependent on their ability initially to produce a negative salt and water balance and, during long-term treatment, to prevent sodium retention. This effect on body sodium and water stores produces both short-term and long-term hemodynamic adjustments that account for the arterial blood pressure reduction. There is a wide variety of diuretic drugs available with differing potencies and renal sites of action. All, however, have similar antihypertensive potential when given in equal diuretic dosages. Dietary sodium restriction is equally effective in lowering arterial blood pressure, but its usefulness is sharply limited by cultural dietary habits.

Author Affiliations
Cleveland

From the Research Division, the Cleveland Clinic Foundation and the Cleveland Clinic Educational Foundation, Cleveland.

Footnotes
Received for publication Oct 23,1973; accepted Jan 28, 1974.

Reprint requests to 9500 Euclid, Cleveland, OH 44106 (Dr. Dustan).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Paradoxical hypotension following increased hematocrit and blood viscosity
Martini et al.
Am. J. Physiol. Heart Circ. Physiol. 2005;289:H2136-H2143.
ABSTRACT | FULL TEXT  

Contribution of Angiotensin-(1-7) to Blood Pressure Regulation in Salt-Depleted Hypertensive Rats
Iyer et al.
Hypertension 2000;36:417-422.
ABSTRACT | FULL TEXT  

Artefacts in Measurement of Blood Pressure and Lack of Target Organ Involvement in the Assessment of Patients with Treatment-Resistant Hypertension
Mejia et al.
ANN INTERN MED 1990;112:270-277.
ABSTRACT  

Dietary Sodium Restriction as Adjunctive Treatment of Hypertension
Weinberger et al.
JAMA 1988;259:2561-2565.
ABSTRACT  

Medical Management of Hypertension
Hutchinson
ANGIOLOGY 1979;30:558-567.
 

Resistant Hypertension: Diagnosis and Management
GIFFORD and TARAZI
ANN INTERN MED 1978;88:661-665.
ABSTRACT  

Therapy for Multifactorial Hypertension
TARAZI
ANN INTERN MED 1978;88:705-706.
ABSTRACT