This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Phillip G. Schmid, MD; Francois M. Abboud, MD

Arch Intern Med. 1974;133(6):935-945.

Abstract
The precise role of neurogenic and humoral mechanisms in the pathogenesis of hypertension cannot be defined. Most likely several mechanisms are interacting. These may differ in the early phases of hypertension if trigger mechanisms are involved and in later phases of sustained hypertension if adaptive changes create a situation of hyperresponsiveness even to normal stimuli. The mechanisms discussed in this review may apply to normal circulatory regulation as well as to human essential, renal, steroid, neurogenic, or different experimental models of hypertension. No attempt is made to assign specific mechanisms to certain types of hypertension. In some types, more than one proposed mechanism may be active.

Author Affiliations
Iowa City

From the Cardiovascular Division, Department of Internal Medicine, University of Iowa College of Medicine, and the Veterans Administration Hospital, Iowa City.

Footnotes
Received for publication Dec 27,1973; accepted Jan 28, 1974.

Reprint requests to Veterans Administration Hospital, Rm 9W-81, Iowa City, IA 52240 (Dr. Schmid).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?