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Hypertension and the Brain
Burton A. Sandok, MD;
Jack P. Whisnant, MD
Arch Intern Med. 1974;133(6):947-954.
Abstract
Hypertension is detrimental to the brain and appears to present a clearly identifiable risk factor in the profile of the stroke-prone individual. Increased blood pressure may alter brain function by acceleration of cerebral atherosclerosis or by initiating a series of pathologic changes in small arteries (lipohyalinosis). The results of these vascular derangements appear to be parenchymal infarctions, commonly encountered in both normotensive and hypertensive patients, and intracerebral hemorrhages and small lacunar infarcts, which are almost exclusively confined to hypertensive brains. Physiologic, pathologic, clinical, and epidemiologic data support the thesis that treatment of hypertension is associated with decreased morbidity and a decrease in the incidence of subsequent cerebrovascular disease.
Author Affiliations
Rochester, Minn
From the Department of Neurology and the Clinical Cerebrovascular Research Center, Mayo Clinic and Mayo Foundation, Rochester, Minn.
Footnotes
Received for publication Oct 23,1973; accepted Jan 28, 1974.
Reprint requests to Mayo Clinic, 200 First St, SW, Rochester, MN 55901 (Dr. Sandok).
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