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Biological Properties of Myeloma Proteins
C. Kirk Osterland, MD;
Luis R. Espinoza, MD
Arch Intern Med. 1975;135(1):32-36.
Abstract
The paraproteins frequently cause major symptoms in patients with plasma cell dyscrasias. This may be due to their quantity in the circulation, to some unusual physicochemical property, or to a biological effect resulting in interaction with other serum proteins. Detection of antibody-combining activity in myeloma proteins has led to important new information on combining-site structure and the kinetics of antigen-antibody-combining activity. Some antibody-combining specificities seem to be present in a higher than expected frequency. As yet, no major therapeutic advances have followed this more precise characterization of the paraprotein, though some interesting possibilities have been explored in animal models.
Author Affiliations
From McGill University School of Medicine, Division of Immunology, Royal Victoria Hospital, Montreal.
Footnotes
Received for publication Feb 20, 1974; accepted March 7.
Read before the Symposium on Myeloma, Atlanta, Oct 22, 1973.
Reprint requests to Royal Victoria Hospital, Montreal H3A 1A1 (Dr. Osterland).
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