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Correlation of Abnormal Immunoglobulin With Clinical Features of MyelomaA Cooperative Study by Acute Leukemia Group B
Arch Intern Med. 1975;135(1):46-52.
Abstract
Physical and chemical characteristics of the abnormal immunoglobulin as well as the immunoglobulin type are important determinants of the clinical features and prognosis in myeloma. A review of 270 cases of myeloma studied by the Acute Leukemia Group B showed that survival was adversely affected by azotemia. The presence of Bence Jones proteinuria adversely influenced survival even in patients who were not initially azotemic. The presence of  -type Bence Jones proteinuria resulted in greatly shortened survival in contrast to  -type Bence Jones proteinuria in the absence, or presence, of a serum IgG M-protein. The adverse effect of -type Bence Jones protein could not be demonstrated in patients with IgA myeloma. Patients with IgA myeloma were found to have a noticeably shorter survival than those with IgG myeloma.
Footnotes
Received for publication March 7, 1974; accepted May 16.
For a complete list of participants see p 52.
Read before the Symposium on Myeloma, Atlanta, Oct 22, 1973.
Reprint requests to Hematology Research Laboratory, 2 Maynard St, Hanover, NH 03755 (Dr. O. Ross McIntyre).
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