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Review of 133 Cases

Zygmunt Jancelewicz, MD, FRCP(C); Kiyoshi Takatsuki, MD; Susumi Sugai, MD; Waldemar Pruzanski, MD, FRCP(C), FACP

Arch Intern Med. 1975;135(1):87-93.

Abstract
One hundred thirty-three patients had IgD myeloma. The IgD comprises 0.8% of M-components in general and 2.1% of myelomas in particular. Males predominate and 65% of the patients are younger than 60 years at the diagnosis. More than half of the patients have lymphadenopathy, hepatomegaly, or splenomegaly. Extraosseous spread and amyloidosis are frequent. Severe anemia and azotemia are common. Total serum protein and IgD M-component levels are usually not high. -Type light chains are found in 90% of IgD M-components. Bence Jones proteinemia is frequent and Bence Jones proteinuria appears in almost all patients. Mean survival is 13.7 months from diagnosis. The IgD is different from IgG and IgA myeloma, indicating that the clinical picture and course of multiple myeloma may be related to the class and type of M-component.

Author Affiliations
From the Immunoglobulin Diagnostic and Research Centre of the University of Toronto, the Wellesley Hospital, Toronto (Drs. Jancelewicz and Pruzanski), and the Department of Medicine, Kyoto University, Kyoto, Japan (Drs. Takatsuki and Sugai).

Footnotes
Received for publication March 7, 1974; accepted May 16.

Reprint requests to the Wellesley Hospital, Toronto, Ontario M4Y, 1J3, Canada (Dr. Pruzanski).

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