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Low-Renin HypertensionOccurrence in Vascular Complications
Subhash C. Gulati, MD;
Bertram J. Channick, MD;
E. Victor Adlin, MD;
C. Miller Biddle, MD;
Allan D. Marks, MD
Arch Intern Med. 1975;135(2):260-263.
Abstract
Two hundred one patients with essential hypertension, who had studies of their renin-aldosterone system performed between April 1967 and December 1972, were surveyed for myocardial infarction or cerebrovascular accident. Of the patients, 42% had low plasma renin activity. Myocardial infarctions or cerebrovascular accidents were documented in 15% of those with low plasma renin activity and in 5% of those with normal plasma renin activity. When adjustments were made for differences in age and blood pressure, a protective effect in low-renin hypertension was not evident. When black patients were considered separately, there was no difference in diastolic blood pressure; however, vascular complications were not less frequent in low-renin hypertensives. The results suggest that low plasma renin activity does not protect against the development of vascular complications in essential hypertension.
Author Affiliations
From the Section of Endocrinology, Department of Medicine, Temple University Health Sciences Center, Philadelphia.
Footnotes
Received for publication April 2, 1974; accepted April 29.
Read in part before the 54th annual session of the American College of Physicians, Chicago, 1973.
Reprint requests to 3401 N Broad St, Philadelphia, PA 19140 (Dr. Channick).
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