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Polyarthritis Associated With Type IV Hyperlipoproteinemia
Robert B. Buckingham, MD;
Giles G. Bole, MD;
David R. Bassett, MD
Arch Intern Med. 1975;135(2):286-290.
Abstract
Twelve patients had undiagnosed articular disease associated with type IV hyperlipoproteinemia. Objective joint findings involved both large and small joints. Disease was bilateral but asymmetrical and oligoarticular. Synovitis was mildly inflammatory and persistent rather than episodic in nature, and disability was minimal. Serial clinical, laboratory, and radiographic assessment excluded other currently recognized forms of rheumatic disease. Joint radiographs demonstrated large metaphyseal and epiphyseal cysts in five patients. Synovioanalysis and synovial biopsy results are reported in two patients. These cases appear to constitute a clinically homogeneous group. The concurrence of a distinctive articular syndrome and type IV hyperlipoproteinemia suggests a possible causal relationship.
Author Affiliations
From the Rackham Arthritis Research Unit and Hyptertension-Hyperlipidemia Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor. Dr. Buckingham is now with the University of Pittsburgh School of Medicine, Pittsburgh.
Footnotes
Received for publication Feb 19, 1974; accepted Sept 4.
Read in part at the 36th Annual Meeting of the American Rheumatism Association, Dallas, June 8, 1972.
Reprint requests to 985 Scaife Hall, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261 (Dr. Buckingham).
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