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Donald D. Stevenson, MD; David A. Mathison, MD; Eng M. Tan, MD; John H. Vaughan, MD

Arch Intern Med. 1975;135(6):777-783.

Abstract
Asthmatic patients were identified as having asthma on the basis of lung function studies (76%), objective physical findings of asthma (11%), or a strong history of asthma (13%). Each of the 234 patients so identified was assigned to an asthma subgroup determined by careful clinical assessment of the major provoking factor or factors for his asthmatic episodes; minor provoking factors were also identified. Only 20% of the patients had asthmatic episodes provoked by a single factor. Most asthmatics had at least one major and one or more minor provoking factor(s). Reagin-mediated mechanisms constituted the major provoking factor in 25% of patients and were a minor provoking factor in an additional 20% of the patients. Thus, in only 45% of the patients, were reaginic mechanisms responsible for some part of their asthmatic episodes.

Author Affiliations
From the Division of Allergy and Immunology, Scripps Clinic and Research Foundation, La Jolla, Calif.

Footnotes
Received for publication March 7, 1974; accepted June 28, 1974.

Reprint requests to Scripps Clinic and Research Foundation, 476 Prospect St, La Jolla, CA 92037 (Dr. Stevenson).

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