This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nonspecificity of Aminoaciduria and Diagnosis of Occult Disease

Vincent M. Riccardi, MD; Vivian E. Shih, MD; Lewis B. Holmes, MD; George L. Nardi, MD

Arch Intern Med. 1975;135(6):822-825.

Abstract
Hereditary pancreatitis appears in many different ways and in a variety of age groups, spanning both pediatric and adult medicine. The variable expression of hereditary pancreatitis is emphasized by the difficulty in diagnosing it in a patient obviously at risk because of a severely affected father and son. The morphine prostigmine test and hypotonic duodenogram were most helpful. Aminoaciduria previously associated with this disorder is coincidental or nonspecifically related to acute pancreatic inflammation. The increased risk for pancreatic carcinoma (about 20%) is emphasized by the concern for that complication in the proband's grandfather.

Author Affiliations
From the Genetics Unit, Childrens Service, the Neurology and Surgery Services, Massachusetts General Hospital, and the departments of pediatrics, neurology, and surgery, Harvard Medical School, Boston. Dr. Riccardi is now at the University of Colorado Medical Center, Denver.

Footnotes
Received for publication June 12, 1974; accepted Oct 3.

Reprint requests to 4200 E Ninth Ave, Denver, CO 80220 (Dr. Riccardi).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Familial Chronic Recurrent Pancreatitis in Identical Twins: Case Report and Review of the Literature
Freud et al.
Arch Surg 1992;127:1125-1128.
ABSTRACT  

Idiopathic Hereditary Pancreatitis: Experience With Surgical Treatment
Williams et al.
Arch Surg 1982;117:408-412.
ABSTRACT