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Estrogen ReceptorTherapeutic Guide in Undifferentiated Metastatic Carcinoma in Women
Harvey M. Golomb, MD;
Sharon Thomsen, MD
Arch Intern Med. 1975;135(7):942-945.
Abstract
Assay for estrogen receptor content was strongly positive in a postmenopausal patient with metastatic adenocarcinoma whose primary site of origin was undeterminable. Bilateral oophorectory and adrenalectomy were performed, resulting in a progression-free period of six months. Estrogen receptor content was determined in other neoplasms, both benign and malignant. Estrogen receptor was present in a high percentage of benign and in one case of malignant endometrial neoplasms. No other neoplasm had a positive assay except for one case of papillary adenocarcinoma of the ovary. Three normal ovaries had negative assays. The presence of estrogen receptor can be used as a therapeutic guide in undifferentiated metastatic carcinoma after exclusion of abnormal pelvic findings in women.
Author Affiliations
From the departments of medicine and pathology, University of Chicago, Pritzker School of Medicine, the University of Chicago Cancer Research Center, and the Franklin McLean Memorial Research Institute (operated by the University of Chicago for the US Atomic Energy Commission), Chicago.
Footnotes
Received for publication Oct 7, 1974; accepted Dec 19.
Reprint requests to Box 420, 950 E 59th St, Chicago, IL 60637 (Dr. Golomb).
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