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Susceptibility to Persistence of Australia Antigen
Alton I. Sutnick, MD;
Sylvia J. Bugbee;
W. Thomas London, MD;
Francesco Peyretti, MD;
Samuel Litwin, PhD;
Baruch S. Blumberg, MD, PhD
Arch Intern Med. 1975;135(8):1072-1074.
Abstract
To test the hypothesis that liver function is different in populations with inherited susceptibility to persistent Australia antigen (hepatitis B surface antigen [HBsAg]), Sardinians living in Turin, Italy, were compared with their native Turinese neighbors. The study was controlled for age, sex, place of birth, and presence or absence of persistent HBsAg. Slight differences in liver function were found in the Sardinians compared with the Turinese. Their values were in the direction of abnormality. Sardinians also had considerably higher serum  -globulin levels than the Turinese. The levels of  2-globulin by electrophoresis correlated with the presence of HBsAg.
Author Affiliations
From the Institute for Cancer Research, the Fox Chase Cancer Center (Drs. Sutnick, London, Litwin, and Blumberg, and Ms. Bugbee), Philadelphia, and the Blood Bank of the City of Turin, Turin, Italy (Dr. Peyretti).
Footnotes
Received for publication Sept 6,1974; accepted Nov 26.
Reprint requests to 7701 Burholme Ave, Fox Chase, Philadelphia, PA 19111 (Dr. Sutnick).
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