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  Vol. 135 No. 9, September 1975 TABLE OF CONTENTS
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Glucagon-Blood Catecholamine Test

Use in Isolated and Familial Pheochromocytoma

Aristarco G. Siqueira-Filho, MD; Sheldon G. Sheps, MD; Frank T. Maher, MD; Nai-Siang Jiang, PhD; Lila R. Elveback, PhD

Arch Intern Med. 1975;135(9):1227-1231.


Abstract



In 149 cases, blood pressure response to glucagon test did not exceed 20/10 mm Hg more than the response in the cold pressor test control and was considered negative. Plasma catecholamine level increases may be seen in 95% of patients without pheochromocytomas. Among six patients with pheochromocytomas, urinary metanephrine levels were of diagnostic importance in two with isolated pheochromocytoma and in one with the multiple endocrine neoplasia of type 2 (MEN-type 2). Urinary metanephrine determinations yielded falsenegative results in three patients with MEN-type 2, while vanilmandelic acid level was normal in one and nephrotomograms were positive in two of these three. These results suggest that the early diagnosis of pheochromocytoma in patients with MEN-type 2 may be difficult and may require multiple biochemical and roentgenographic investigations.



Author Affiliations



From the Mayo Clinic and Mayo Foundation, Rochester, Minn.


Footnotes



Received for publication July 23, 1974; accepted Feb 3, 1975.

Reprint requests to Section of Publications, Mayo Clinic, 200 First St SW, Rochester, MN 55901 (Dr. Siqueira-Filho).



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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Improved Safety of Glucagon Testing for Pheochromocytoma by Prior {alpha}-Receptor Blockade: A Controlled Trial in a Patient With a Mixed Ganglioneuroma/Pheochromocytoma
Elliott et al.
Arch Intern Med 1989;149:214-216.
ABSTRACT  

Intraoperative Cardiovascular Crisis Caused by Glucagon
Schorr and Rogers
Arch Surg 1987;122:833-834.
ABSTRACT  

Hypertensive Crisis Induced by Metoclopramide in Patient with Pheochromocytoma
Abe et al.
ANGIOLOGY 1984;35:122-128.
ABSTRACT  





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