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James R. Oster, MD; Stanley M. Lee, MD; Laura E. Lespier, MD; Edgardo L. Pellegrini, MD; Carlos A. Vaamonde, MD

Arch Intern Med. 1976;136(1):30-35.

Abstract
Nine sickle cell trait and nine control subjects underwent six-hour ammonium chloride acid loading. Maximal urine osmolality and renal hemodynamics were studied separately. Base line arterial pH, carbon dioxide pressure (Pco₂), and [HCO₃] were normal and comparable in the two groups. After ammonium chloride loading, urine pH decreased to 5.3 or less in all, and maximal excretion of ammonium and titratable and net acid was comparable as was urine minus blood Pco₂ after bicarbonate loading. The ammonium chloride acidosis caused a small decrease in red blood cell 2,3-diphosphoglycerate levels but no alteration In oxygen pressure at 50% saturation at pH 7.4, sickling, or adverse effects. Control and sickle cell trait subjects had comparable renal hemodynamics but maximal urine osmolality was lower in sickle-cell trait subjects.

Adults with sickle cell trait have diminished renal concentrating ability and normal renal acidification and hemodynamics.

(Arch Intern Med 136:30-35, 1976)

Author Affiliations
From the Nephrology Section, Medical and Research Services, Miami Veterans Administration Hospital, and Department of Medicine, University of Miami School of Medicine, Miami, Fla.

Footnotes
Received for publication Dec 27, 1974; accepted April 12, 1975.

Reprint requests to 1201 NW 16th St, Miami, FL 33125 (Dr. Vaamonde)..

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