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Results of a Long-Term Prospective Study

Ernest L. Mazzaferri, MD; James C. Reynolds, MD; Lt Col Robert L. Young, MC; Lt Col Charles N. Thomas, MC; Alfred F. Parisi, MD

Arch Intern Med. 1976;136(1):50-56.

Abstract
It has been suggested that propranolol hydrochloride alone is effective in the treatment of thyrotoxicosis. To test this hypothesis, eight mildly thyrotoxic individuals were prospectively studied for an average of eight months, during which propranolol alone was administered and thyroid function tests, cardiac systolic time intervals, and body densities were sequentially measured. Two patients became euthyroid. The others had adequate but incomplete symptomatic control. Weight loss was not corrected, but no changes in lean body mass were induced. The augmented myocardial contractility of thyrotoxicosis, as determined by systolic time intervals, improved but failed to return completely to normal. Thus, systolic time intervals are a practical means of following the peripheral response to chronic beta-adrenergic blockade in thyrotoxic patients. However, these observations do not support the use of propranolol alone as the first choice of therapy for thyrotoxicosis.

(Arch Intern Med 136:50-56, 1976)

Author Affiliations
USAF; USAF

From the Division of Endocrinology and Metabolism, Ohio State University Hospitals, Columbus (Drs. Mazzaferri and Reynolds); the divisions of endocrinology and metabolism (Dr. Young) and cardiology (Dr. Thomas), Wilford Hall USAF Medical Center, San Antonio, Texas; and the Division of Cardiology, Baltimore Veterans Administration Hospital, Baltimore (Dr. Parisi).

Footnotes
Received for publication Jan 7, 1975; accepted March 26.

Reprint requests to Room N-1111 University Hospital, 410 W Tenth Ave, Columbus, OH 43210 (Dr. Mazzaferri).

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