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Management With Sequential Splenectomy and Chemotherapy

Robert W. Carey, MD; Andrew McGinnis, MD; Bernard M. Jacobson, MD; Angelina Carvalho, MD

Arch Intern Med. 1976;136(1):62-66.

Abstract
Three patients had severe, symptomatic idiopathic thrombocytopenic purpura (ITP) complicating chronic lymphocytic leukemia (CLL) that was refractory to prednisone treatment but that responded to splenectomy alone or in addition to immunosuppressive-cytotoxic treatment. Evidence of high titer of an antiplatelet factor, most likely an antibody, was corroborated in one case by the ¹⁴C-platelet serotonin release assay. This experience suggests that the treatment of ITP complicating CLL is similar to that of ITP not associated with lymphoproliferative disorders.

(Arch Intern Med 136:62-66, 1976)

Author Affiliations
From the Massachusetts General Hospital, Boston.

Footnotes
Received for publication June 6, 1974; accepted March 10, 1975.

Reprint requests to 100 Blossom St, Boston, MA 02114 (Dr. Carey).

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