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The Role of Renin

Richard F. Spark, MD; Solomon Berg, MD

Arch Intern Med. 1976;136(10):1097-1100.

Abstract
Three patients developed hypertension following renal trauma. Trauma produced perinephric hematoma in two and renal artery thrombosis in one. Renal vein plasma renin activity (PRA) from the traumatized kidney was three to eight times greater than renal vein PRA from the untraumatized (contralateral) kidney. Peripheral PRA was elevated in all. A surgical operation lowered peripheral PRA to normal in all, but corrected hypertension in only two of three. Preoperative medical treatment with renin-suppressing pharmacologic agents correctly predicted this response to surgery. Postoperative renal vein PRA in the remaining hypertensive patient demonstrated that surgery successfully alleviated the abnormality in renin secretion. These studies suggest that excessive renin secretion initiate but other unidentified factors may contribute to the hypertension observed after renal trauma.

(Arch Intern Med 136:1097-1100, 1976)

Author Affiliations
From the Departments of Medicine (Dr Spark) and Urology (Dr Berg), Beth Israel Hospital and Harvard Medical School, Boston.

Footnotes
Received for publication Dec 22, 1975; accepted March 22, 1976.

Reprint requests to Beth Israel Hospital, 330 Brookline Ave, Boston, MA 02215 (Dr Spark).

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