This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (63)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Nancy E. Gary, MD; Louis Buzzeo, MD; John Salaki, MD; Robert P. Eisinger, MD

Arch Intern Med. 1976;136(10):1101-1104.

Abstract
Five patients are described in whom only gentamicin sulfate appeared responsible for acute renal failure. Subjects received 1.2 to 2.88 gm over 12 to 18 days. All were over 45 years of age, and premorbid kidney abnormalities may have enhanced susceptibility to toxic effects of the drug. Renal failure appeared 8 to 17 days after beginning gentamicin therapy and was characterized by creatinine clearances 4 to 10 ml/min, urine to plasma creatinine ratios < 20, urinary sodium concentrations 16 to 60 mEq/ liter, proteinuria, and cylindruria. Oliguria was not observed and this feature may impair recognition of kidney damage. Clinical recovery required an average of 42 days and was complete in four of five patients. Gentamicin alone may be nephrotoxic and should be given with particular caution to the elderly and those with even mild kidney abnormalities.

(Arch Intern Med 136:1101-1104, 1976)

Author Affiliations
From the Departments of Medicine, College of Medicine and Dentistry of New Jersey Rutgers Medical School, Piscataway, NJ, and St Vincent's Hospital and Medical Center of New York. Dr Buzzeo is now with the Department of Medicine, New York University School of Medicine, New York, and Dr Salaki is now with the Department of Medicine, College of Medicine and Dentistry of New Jersey-The New Jersey Medical School, Newark.

Footnotes
Accepted for publication April 14, 1976.

Reprint requests to CMDNJ-Rutgers Medical School, Raritan Valley Hospital, 275 Greenbrook Rd, Greenbrook, NY 08812 (Dr Gary).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Acute Renal Failure After Enhanced Computed Tomography
Gordon and Barnes
Arch Intern Med 1983;143:1042-1043.
ABSTRACT  

Gentamicin Tissue Accumulation and Nephrotoxic Reactions
Schentag et al.
JAMA 1978;240:2067-2069.
ABSTRACT  

Ampicillin Sodium and Nephrotoxicity-Reply
Gary
Arch Intern Med 1977;137:812-812.
ABSTRACT