This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Masumasa Horisawa, MD; Telfer B. Reynolds, MD

Arch Intern Med. 1976;136(10):1135-1137.

Abstract
Ten patients with severe liver disease and the hepatorenal syndrome underwent exchange transfusions with 9 to 16 units of fresh heparinized blood to improve renal function by either removing a vasoconstrictive substance or adding a vasodilatory substance. One patient recovered from renal failure within ten days without showing natriuresis. The renal function of one patient improved somewhat, but he died 35 days after the transfusion. The other eight patients died from 1 to 35 days after exchange transfusion, without any appreciable improvement in renal function. In six patients, renin substrate levels increased after the transfusion, but renal function remained unchanged. The results of this study failed to support a humoral concept of pathogenesis of the hepatorenal syndrome.

(Arch Intern Med 136:1135-1137, 1976)

Author Affiliations
From the Department of Medicine, University of Southern California School of Medicine, Los Angeles, and the Liver Service, John Wesley County Hospital, Los Angeles. Dr Horisawa was a clinical research fellow of the University of Southern California; he is now at the Nagoya University School of Medicine, Nagoya, Japan.

Footnotes
Received for publication Oct 21, 1975; accepted March 29, 1976.

Reprints not available.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?