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Idiopathic Pulmonary HemosiderosisUltrastructural Studies and Response to Azathioprine
Henry Yeager, Jr, MD;
Deborah Powell, MD;
Richard M. Weinberg, MD;
Heinz Bauer, MD;
Joseph A. Bellanti, MD;
Sol Katz, MD
Arch Intern Med. 1976;136(10):1145-1149.
Abstract
Two boys are presented who fulfilled criteria for a diagnosis of idiopathic pulmonary hemosiderosis. A lung biopsy specimen from the first patient showed alveolar-capillary basement membrane abnormalities, together with abnormalities of capillary endothelial cells and hemosiderin-laden macrophages. A lung biopsy specimen from the second patient showed mainly capillary endothelial abnormalities and interstitial fibrosis. Both patients had a noticeable improvement in symptoms and relative stabilization of their roentgenographic and pulmonary function abnormalities following azathioprine therapy.
(Arch Intern Med 136:1145-1149, 1976)
Author Affiliations
From the departments of medicine (Drs Yeager, Weinberg, and Katz), pediatrics (Dr Bellanti), and pathology (Drs Powell and Bauer), Georgetown University School of Medicine, Washington, DC.
Footnotes
Received for publication Jan 28, 1976; accepted March 2.
Reprint requests to Georgetown University Hospital, 3800 Reservoir Rd NW, Washington, DC 20007 (Dr Yeager).
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