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James R. Oster, MD; Guido O. Perez, MD; Mark S. Rosen, MD

Arch Intern Med. 1976;136(10):1179-1180.

Abstract
We describe a 52-year-old man who, following the discontinuation of massive intake of sodium bicarbonate, in the absence of renal insufficiency, developed progressive hyperkalemia and hyponatremia in association with hyporeninemic hypoaldosteronism. The mechanism of this syndrome is not known, but may involve suppression of the renin-angiotensin-aldosterone axis by chronic volume expansion.

(Arch Intern Med 136:1179-1180, 1976)

Author Affiliations
From the Medical and Research Services, Veterans Administration Hospital, and the Department of Medicine, University of Miami School of Medicine, Miami.

Footnotes
Received for publication Feb 10, 1976; accepted April 14.

Reprint requests to Veterans Administration Hospital, 1201 NW 16th St, Miami, FL 33125 (Dr Oster).

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