This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citing articles on HighWire  • Citing articles on Web of Science (9)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

A Pharmacological Study of Its Occurrence After Intrathecal Administration in a Patient With Renal Failure

Ed C. Cadman, MD; Walter B. Lundberg, MD; Joseph R. Bertino, MD

Arch Intern Med. 1976;136(11):1321-1322.

Abstract
Methotrexate pharmacokinetic studies, performed on a patient with renal impairment who had toxic effects following 20 mg/sq m of intrathecally administered methotrexate, demonstrated prolonged serum concentrations of the drug, which accounted for the condition. After the return of normal renal function, pharmacokinetic studies were repeated following the same dose and route of administration of methotrexate. On this occasion there was a rapid clearance of serum methotrexate below toxic levels.

(Arch Intern Med 136:1321-1322, 1976)

Author Affiliations
From the Section of Medical Oncology, Yale University School of Medicine, New Haven, Conn.

Footnotes
Accepted for publication April 21, 1976.

Reprint requests to Section of Medical Oncology, Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CN 06510 (Dr Cadman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Leukocytoclastic Vasculitis After High-Dose Methotrexate
NAVARRO et al.
ANN INTERN MED 1986;105:471-472.
ABSTRACT