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Elevated IgM Levels, Edema, and Fatigue Syndrome
Barry J. Cooper, MD;
Roy Patterson, MD
Arch Intern Med. 1976;136(12):1366-1369.
Abstract
Two patients with nonpitting edema associated with extreme fatigue were found to have hyperimmunoglobulinemia M and eosinophilia. Additional laboratory abnormalities included an elevated ESR and the presence of rheumatoid factor.
One patient had the symptom complex continually, and it was controlled with minimal amounts of prednisone. The other patient had intermittent symptoms, with eosinophilia in the asymptomatic state and decreased eosinophil counts while symptomatic. His symptomatic episodes were diminished in duration by methylprednisolone. We believe these cases, which have been evaluated for eight and four years, respectively, constitute a new syndrome that has substantial morbidity, but that is apparently benign and that can be controlled with corticosteroids.
(Arch Intern Med 136:1366-1369, 1976)
Author Affiliations
From the Section of Allergy-Immunology, Department of Medicine, Northwestern University Medical School, Chicago.
Footnotes
Received for publication Feb 4, 1976; accepted April 5.
Reprint requests to Section of Allergy-Immunology, Department of Medicine, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611 (Dr Patterson).
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