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Clinical Usefulness in Lymphoma Patients

James E. Seabold, MD; May L. Votaw, MD; John W. Keyes, Jr, MD; William D. Foley, MD; S. Balachandran, MD; Satineder P. Gill, MD

Arch Intern Med. 1976;136(12):1370-1374.

Abstract
Gallium citrate Ga 67 (₆₇Ga) scans were performed in 50 consecutive lymphoma patients who underwent routine staging. The overall accuracy of⁶⁷Ga scans was greater than 80% for all nodal sites except the spleen (63%). Sensitivity was greater than 88% in the neck and mediastinum, 67% in the abdomen-pelvis, and 33% for the spleen. Specificity was greater than 85% for all nodal sites except for the mediastinum (67%). The accuracy of pedal lymphangiograms was 75%, sensitivity 87%, and specificity 68%. Gallium 67 scans complemented the lymphogram in the abdomen-pelvis but, due to limited sensitivity and high number of equivocal studies (16%), did not replace it. Infraclavicular, pectoral, and mediastinal lesions were detected by⁶⁷Ga scans when missed by other means. In 20% to 25% of patients,⁴⁷Ga scans provided information not afforded by other diagnostic studies and are therefore considered an important staging procedure for lymphoma patients.

(Arch Intern Med 136:1370-1374, 1976)

Author Affiliations
From the Departments of Internal Medicine (Drs Seabold, Votaw, Keyes, and Balachandran) and Radiology (Drs Foley and Keyes), University of Michigan Medical School. Ann Arbor. Dr Seabold is now with the University of Texas System Cancer Center, Houston.

Footnotes
Received for publication Feb 11, 1976; accepted April 27.

Reprint requests to Section of Nuclear Medicine, University of Texas System Cancer Center, Texas Medical Center, M.D. Anderson Hospital and Tumor Institute, Houston, TX 77025 (Dr Seabold).

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