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Jerry L. Rosenbaum, MD, FACP; Mark S. Kramer, MD; Rasib Raja, MD, FACP

Arch Intern Med. 1976;136(3):263-266.

Abstract
Eight patients with drug intoxication were hemoperfused on ten occasions at a blood-flow rate of 300 ml/min with a 650-gm column of Amberlite XAD-4 resin, which is a macroreticular resin with a specific adsorptive attraction for lipid-soluble organic molecules. Column clearances of glutethimide and a variety of barbiturates ranged from 207 to 300 ml/min for treatment sessions extending from 2 1/2 to ten hours. After ingestion of 75 gm of glutethimide, one patient received hemoperfusion on three successive days for nine, ten, and eight hours, respectively. She recovered after the column removed over 30 gm of drug. The patients demonstrated dramatic clinical responses with no evidence of meaningful toxic reactions. Column hemoperfusion with Amberlite XAD-4 resin was simpler and more effective than any known method of removing barbiturates and glutethimide from the blood of patients with drug overdoses.

(Arch Intern Med 136:263-266, 1976)

Author Affiliations
From the Kraftsow Renal Section, Department of Medicine, and the Women's League for Medical Research Laboratories, Albert Einstein Medical Center, Philadelphia.

Footnotes
Received for publication Feb 19, 1975; accepted June 12.

Reprint requests to Kraftsow Renal Section, Department of Medicine, Albert Einstein Medical Center, York and Tabor Roads, Philadelphia, PA 19141 (Dr Rosenbaum).

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