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Clinical Characteristics of Patients

Stephen J. Farber, MD; Giles G. Bole, MD

Arch Intern Med. 1976;136(4):425-431.

Abstract
Forty-four patients with antibodies to ribonuclease-sensitive extractable nuclear antigen (ENA), ribonuclease-resistant ENA, or both, are described. Most patients with antiribonucleoprotein (anti-RNP) antibodies have overlapping features of systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), and polymyositis, and have a low incidence of nephritis. Most patients with antibody solely to ribonuclease-insensitive ENA have SLE; these patients with SLE are typical of the general SLE population, except that they demonstrate an increased incidence of Raynaud phenomenon. Furthermore, it is shown that antibody to ENA may occur in other rheumatic and nonrheumatic diseases, and that not all patients who have a clinical overlap of SLE and PSS that is suggestive of mixed connective tissue disease have anti-RNP antibody.

(Arch Intern Med 136:425-431, 1976)

Author Affiliations
From the Rackham Arthritis Research Unit, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor. Dr Farber is now at the University of Virginia School of Medicine, Charlottesville.

Footnotes
Received for publication Nov 20, 1975; accepted Dec 15.

Reprint requests to R4633 Kresge I, University of Michigan Medical School, Ann Arbor, MI 48104 (Dr Farber).

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