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Elliott Eisenbud, MD; Carolyn C. LoBue, MD, PhD

Arch Intern Med. 1976;136(6):688-691.

Abstract
It is now recognized that magnesium plays an important role in calcium homeostasis. Although the effects of hypomagnesemia have been frequently reported, little has been written to suggest a clinically important role for hypermagnesemia. A case is reported in which severe hypocalcemia, with a low plasma parathyroid hormone (PTH) concentration, resulted from the therapeutic use of magnesium sulfate for toxemia of pregnancy. Following recovery, the parathyroid glands were shown to respond normally to a phosphate load. It is suggested that the hypermagnesemia directly suppressed PTH secretion, resulting in symptomatic hypocalcemia.

(Arch Intern Med 136:688-691, 1976)

Author Affiliations
From the departments of internal medicine (Dr Eisenbud) and obstetrics and gynecology (Dr LoBue), School of Medicine, University of California, Davis.

Footnotes
Received for publication Aug 5, 1975; accepted Dec 10.

Reprint requests to Department of Internal Medicine, School of Medicine, University of California, Davis, CA 95616 (Dr Eisenbud).

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