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Partial Deletion of Long Arm of Chromosome 17A Specific Abnormality in Acute Promyelocytic Leukemia?
Harvey M. Golomb, MD;
Janet Rowley, MD;
James Vardiman, MD;
Joseph Baron, MD;
Gershon Locker, MD;
Sheldon Krasnow, MD
Arch Intern Med. 1976;136(7):825-828.
Abstract
Two patients with acute promyelocytic leukemia had an identical chromosomal abnormality detected by fluorescence banding. In each case, the clinical course was rapidly fatal, and was characterized by a lack of response to chemotherapy with cytarabine and thioguanine, and was complicated by disseminated intravascular coagulation. Bone marrow cells from each patient contained 46 chromosomes; in each instance, however, one chromosome 17 had a deletion of almost one half of the proximal portion of the long arm [del(17)(q11q21 or 22)].
(Arch Intern Med 136:825-828, 1976)
Author Affiliations
From the departments of medicine (Drs Golomb, Rowley, Baron, and Locker) and pathology (Dr Vardiman), University of Chicago Hospitals and Clinics, the Franklin McLean Memorial Research Institute, Chicago, and West Suburban Hospital, Oak Park, Ill (Dr Krasnow).
Footnotes
Received for publication Nov 19, 1975; accepted Dec 15.
Reprint requests to Box 420, University of Chicago Hospitals, 950 E 59th St, Chicago, IL 60637 (Dr Golomb).
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