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Gastrointestinal Side Effects Associated With Clindamycin1,000 Consecutive Patients
John E. Swartzberg, MD;
Rosemary M. Maresca;
Jack S. Remington, MD
Arch Intern Med. 1976;136(8):876-879.
Abstract
The incidence and parameters associated with diarrhea related to clindamycin usage were studied in a population of both inpatients and outpatients. Diarrhea occurred in 66 (6.6%) of the 1,000 patients. In three of them, substantial morbidity was associated with the diarrhea. Of the multiple parameters that were evaluated, a significant association with diarrhea was found only for age (patients over the age of 20 years) (P <.01) and sex (females) (P <.005). Interestingly, dose, duration, and route of administration showed no significant relationship to diarrhea (P >.05).
(Arch Intern Med 136:876-879, 1976)
Author Affiliations
From the Division of Allergy, Immunology, and Infectious Diseases, Palo Alto Medical Research Foundation, Palo Alto, Calif, and the Department of Medicine, Stanford University School of Medicine, Stanford, Calif.
Footnotes
Received for publication Dec 16, 1975; accepted Jan 14, 1976.
Read in part at the 15th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, Sept 24-26, 1975.
Reprint requests to Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 (Dr Remington).
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