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Ronald N. Shore, MD; Harry A. Kiesel, MD; Hugh D. Bennett, MD

Arch Intern Med. 1977;137(10):1465-1467.

Abstract
A 37-year-old man was admitted with bone pain, night sweats, and skin lesions typical of secondary syphilis. His VDRL and FTA-ABS tests were reactive. Roentgenograms of the tibiae, fibulae, radii, and ulnae showed osteolytic lesions. A tibial biopsy examination showed bone necrosis, prominent vascularity, swollen endothelial cells, an intense plasma cell infiltrate, and numerous spirochetes. All manifestations responded to penicillin therapy.

There have been few reports of osteolytic lesions in secondary syphilis. This is the first known case in which such involvement was unequivocally proven by histopathology with the demonstration of spirochetes.

(Arch Intern Med 137:1465-1467, 1977)

Author Affiliations
From the Department of Medicine, Hahnemann Medical College and Hospital, Philadelphia.

Footnotes
Accepted for publication Oct 11, 1976.

Reprint requests to Division of Dermatology, Hahnemann Medical College and Hospital of Philadelphia, 230 N Broad St, Philadelphia, PA 19102 (Dr Shore).

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