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Single-Voided Urine Metanephrine Assays in Screening for Pheochromocytoma
Norman M. Kaplan, MD;
Norman J. Kramer, MD;
O. Bryan Holland, MD;
Sheldon G. Sheps, MD;
Celso Gomez-Sanchez, MD
Arch Intern Med. 1977;137(2):190-193.
Abstract
To facilitate the screening for pheochromocytoma, we have validated the use of single-voided, spot urine specimens for the determination of total metanephrines. Metanephrine excretion was found to be quite constant throughout the day and night in ten patients with essential hypertension and seven patients with pheochromocytoma. The levels in single-voided specimens were closely correlated to those in 24-hour specimens in 100 hypertensive subjects. The mean ± 2 SD metanephrine excretion in single-voided urine specimens from 500 hypertensive subjects was 0.351 ± 0.356 µg/mg of creatinine.
(Arch Intern Med 137:190-193, 1977)
Author Affiliations
From the Department of Internal Medicine, the University of Texas Health Science Center, Dallas (Drs Kaplan, Kramer, Holland, and Gomez-Sanchez), and the Mayo Clinic, Rochester, Minn (Dr Sheps).
Footnotes
Received for publication Feb 4, 1976; accepted May 18.
Reprint requests to the University of Texas Health Science Center, 5323 Harry Hines Blvd, Dallas, TX 75235 (Dr Kaplan).
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