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Oxalosis and Chronic Renal Failure After Intestinal Bypass
David R. Gelbart, MD;
Lynne L. Brewer, MD;
Luis F. Fajardo, MD;
Arvin B. Weinstein, MD
Arch Intern Med. 1977;137(2):239-243.
Abstract
A 45-year-old man underwent a jejunoileal shunt procedure for obesity. Twenty months later he developed severe oxalosis and chronic renal failure, which required maintenance hemodialysis. The sequential observation of two biopsy specimens and the necropsy (over a span of 39 months) suggests that oxalate deposition caused tubular obstruction and destruction with subsequent atrophy of nephrons. This indicates that patients undergoing intestinal bypass are at risk for developing irreversible renal failure due to enteric hyperoxaluria.
(Arch Intern Med 137:239-243, 1977)
Author Affiliations
From the Departments of Medicine (Drs Gelbart and Weinstein) and Pathology (Drs Brewer and Fajardo), Stanford University School of Medicine, Stanford, Calif, and Veterans Administration Hospital (Dr Fajardo), Palo Alto, Calif. Dr Weinstein's current address is Department of Medicine, University of Wisconsin Medical School, Madison.
Footnotes
Accepted for publication Oct 7, 1976.
Reprint requests to Department of Pathology, Stanford Medical School, 300 Pasteur Dr, Stanford, CA 94305 (Dr Fajardo).
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