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Doxorubicin Hydrochloride-Associated Renal Failure
James F. Burke, Jr, MD;
J. Frederick Laucius, MD;
Harvey S. Brodovsky, MD;
Raymond Z. Soriano, MD
Arch Intern Med. 1977;137(3):385-388.
Abstract
Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to those seen following administration of structural analogues of doxorubicin. Daunorubicin hydrochloride, particularly, is known to cause renal failure in experimental animals. Renal function should be monitored in patients receiving doxorubicin.
(Arch Intern Med 137:385-388, 1977)
Author Affiliations
From the Departments of Medicine and Pathology, Jefferson Medical College, Philadelphia.
Footnotes
Accepted for publication June 23, 1976.
Reprint requests to Jefferson Medical College, Nephrology Division, 1025 Walnut St, Philadelphia, PA 19107 (Dr Burke).
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