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Charles G. Popelka, MD; Jerome Kleinerman, MD

Arch Intern Med. 1977;137(4):523-525.

Abstract
Diffuse pulmonary ossification (DPO) was a complication of "shock lung" after aortic valve replacement in a 52-year-old man. The relationship of DPO to shock lung is discussed. A possible mechanism for this complication is based on the development of a fibrin-platelet-fibroblastic interaction that may establish an intraalveolar lattice for collagen deposition by the fibroblast. The development of acidosis and mechanical forcer may potentiate fibroblastic transformation into an osteoblast. The mechanical forcer may influence the shape of the bone in the lung.

(Arch Intern Med 137:523-525, 1977)

Author Affiliations
From the Division of Pathology Research, St Luke's Hospital, and the Department of Pulmonary Medicine, Veterans Administration Hospital (Dr Popelka), Cleveland. Dr Popelka was a trainee in pulmonary medicine in the National Institutes of Health Veterans Administration training program.

Footnotes
Accepted for publication Aug 9, 1976.

Reprint requests to St Luke's Hospital, Division of Pathology Research, 11311 Shaker Blvd, Cleveland, OH 44104 (Dr Kleinerman).

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