Studies with an artificial endocrine pancreas
A. M. Albisser, B. S. Leibel, B. Zinman, F. T. Murray, W. Zingg, C. K. Botz, A. Denoga and E. B. Marliss
Short-term studies with an artificial endocrine pancreas have provided
insights into the pathophysiology of diabetes and demonstrated the ability
of such a system to restore and maintain glucose homeostasis in human
subjects given either their usual diet, a 50 gm oral glucose tolerance
test, or a moderate level of physical exercise. Animals were used to
demonstrate that a peripheral route of insulin delivery by the artificial
pancreas is equivalent to the portal route.
