 |
|
Platelet-Inhibiting Drugs in Thrombotic Thrombocytopenic Purpura
Robert H. Eckel, MD;
Edward B. Crowell, Jr, MD;
Blake E. Waterhouse, MD;
Marek J. Bozdech, MD
Arch Intern Med. 1977;137(6):735-737.
Abstract
Two patients with thrombotic thrombocytopenic purpura were seen. Aspirin, dipyridamole, and sulfinpyrazone were administered to patient 1 after splenectomy, and administration of high-dose prednisone and methylprednisolone failed to induce remission. The platelet count rose, but the patient had a relapse when the dipyridamole dose was tapered. This condition responded to an increase of the drug, and the patient obtained a long-lasting remission. A splenectomy was not performed on patient 2, and all three platelet-inhibiting drugs, together with prednisone, were given. This resulted in a prompt remission that has been sustained for 29 weeks. Morphologic changes in the peripheral blood smear remained for several weeks after other features of the disease had resolved. Thus, in both cases, platelet-inhibiting drugs appeared to induce a remission.
(Arch Intern Med 113:735-737, 1977)
Author Affiliations
From the Department of Medicine, University of Wisconsin, and Methodist Hospitals, Madison, Wis. Dr Eckel is now with the Department of Medicine, University of Washington, Seattle; Dr Crowell is now with Christian Medical College, Ludhiana, Punjab, India; Dr Bozdech is now with the Department of Medicine, University of California at San Francisco.
Footnotes
Accepted for publication July 13, 1976.
Reprint requests to Department of Medicine, University of Washington, Mail Stop RG-20, 1959 NE Pacific, Seattle, WA 98195 (Dr Eckel).
 CiteULike  Connotea  Delicious  Digg  Facebook  Reddit  Technorati  Twitter
What's this?
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Thrombotic Thrombocytopenic Purpura: A Reappraisal
Crain and Choudhury
JAMA 1981;246:1243-1246.
ABSTRACT
Plasma Infusion for Thrombotic Thrombocytopenic Purpura During Pregnancy
Walker et al.
Arch Intern Med 1980;140:981-983.
ABSTRACT
Primary Hemochromatosis With Hereditary Spherocytosis
Zimelman and Miller
Arch Intern Med 1980;140:983-984.
ABSTRACT
Thrombotic Thrombocytopenic Purpura: Combined Treatment with Plasmapheresis and Antiplatelet Agents
MYERS et al.
ANN INTERN MED 1980;92:149-155.
ABSTRACT
|
