This Article  • References  • Full text PDF  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Eva V. Dubovsky, MD; Arnold G. Diethelm, MD; W. Newlon Tauxe, MD

Arch Intern Med. 1977;137(6):738-742.

Abstract
The differentiation of two types of renal graft rejection may be made early in incipient stages by means of a comprehensive renal function study. In the acute cell-mediated form, prolongation of orthoiodohippurate renal transit time as reflected in a diminished excretory index (El) is first observed, followed by a diminution in the effective renal plasma flow (ERPF). On reversal of the process, El precedes ERPF in returning to normal. In chronic humoral rejection, the principle feature is simple reduction of ERPF; transit time within the kidney appears normal. No reversal processes have been observed, although the process may be decelerated. At approximately 100 ml/min ERPF, these kidneys may undergo an acceleration of the clinical failure with rapid deterioration in El and in ERPF. At this point, surgical removal of the kidney has been carried out.

(Arch Intern Med 137:738-742, 1977)

Author Affiliations
From the Divisions of Nuclear Medicine (Drs Dubovsky and Tauxe) and Organ Transplantation (Dr Diethelm), University of Alabama Medical Center, Birmingham, and the Division of Nuclear Medicine, Veterans Administration Hospital, Birmingham, Ala (Drs Dubovsky and Tauxe).

Footnotes
Accepted for publication July 28, 1976.

Reprint requests to Division of Nuclear Medicine, University of Alabama Medical Center, 619 S 19th St, Birmingham, AL 35233 (Dr Dubovsky).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?