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Carcinoembryonic Antigen Titers on Effusion FluidA Diagnostic Tool?
J. Scott Nystrom, MD;
Barbara Dyce, MS;
Jerry Wada, MD;
Joseph R. Bateman, MD;
Bernard Haverback, MD
Arch Intern Med. 1977;137(7):875-879.
Abstract
Carcinoembryonic antigen (CEA) has been demonstrated in tumors and body fluids, suggesting that effusion fluid (EF) CEA titer might separate benign and malignant EF.
Plasma and EF CEA titers were determined on 141 patients with either benign (86) or malignant (55) EF. Although plasma CEA titers separated patients with either a benign or malignant EF 56% of the time, this separation was better accomplished (90% of the time) using EF CEA (P <.0001). A malignant EF was associated with an EF CEA titer  10 ng/ ml or when, in the range 5.0 to 9.9 ng/ml, the EF CEA titer was greater than twice the plasma CEA. Paired plasma and EF CEA titers may aid in determining the benign or malignant origin of an EF.
(Arch Intern Med 137:875-879, 1977)
Author Affiliations
From the Medical Oncology Division, Department of Medicine, University of Southern California, Los Angeles.
Footnotes
Accepted for publication Aug 24, 1976.
Reprint requests to Medical Oncology Division, University of Connecticut Health Center, Farmington, CT 06032 (Dr Nystrom).
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